Curing aging with medical technology:
Aubrey de Grey is a biomedical gerontologist, Chief Science Officer of the SENS Research Foundation and VP of New Technology Discovery at AgeX Therapeutics. He is editor-in-chief of the academic journal Rejuvenation Research, author of The Mitochondrial Free Radical Theory of Aging (1999) and co-author of Ending Aging (2007). He is known for his view that medical technology may enable human beings alive today not to die from age-related causes. Aubrey is also an international adjunct professor of the Moscow Institute of Physics and Technology, a fellow of the Gerontological Society of America, the American Aging Association, and the Institute for Ethics and Emerging Technologies.
EPISODE LINKS:
Sense Research Foundation: https://www.sens.org/
Ending Aging: https://www.amazon.com/Ending-Aging-Rejuvenation-Breakthroughs-Lifetime-ebook/dp/B001ANSSKA
Twitter: https://twitter.com/aubreydegrey
Wikipedia: https://en.wikipedia.org/wiki/Aubrey_de_Grey
INFO:
Podcast website: https://volandino.com
Spotify: https://open.spotify.com/show/3O74ctu6Hv5zZdHYT9Ox3Z
Apple Podcasts: https://podcasts.apple.com/us/podcast/beyond/id1509949724
RSS: https://volandino.com/feed/podcast
Full episodes playlist: https://www.youtube.com/playlist?list=PLXRmG-SrXaHiysqmzKg78kW1g_VBxHyjj
OUTLINE:
01:54 – The 7 kinds of damage that produce aging
05:13 – Loss of cells and stem cell therapy
07:00 – Waste products inside cells – arteriosclerosis and macular degeneration
08:36 – Waste products outside cells – phagocytosis by inmune stimulation
09:20 – Cells dividing when they are not supposed to. Nuclear mutations, cancer, inmunotherapy, telomerase/ALT gene deletion plus periodic stem cell reseeding
09:45 – Death resistant cells: making space for new cells, senescent cells, gene therapy
10:57 – Accumulation of mutations in the Mitochondria, backup copies of the DNA, allotopic expression of the 13 proteins
11:50 – Elasticity, major arteries: AGE-breaking molecules/enzymes
13:15 – Engineered negligible senescence: an engineering approach to fixing aging
14:25 – How much we don’t need to know: Pioneering technologist vs basic scientist mindset
16:17 – Reaching the fundamental understanding – nearly 40 years ago
17:23 – Adapting existing theories to the field of aging, bringing together ideas from other fields.
20:44 – Using soil bacteria to degrade long-lived organic material: bringing ideas from the environmental decontamination field to the field of aging
21:57 – Vulcanization of science: bias against cross-disciplinary work
22:54 – Being an outlier
23:37 – From programming to leading the fight against aging
25:26 – Backups of genes and the key 13 proteins of the Mitochondria
26:23 – What is different and what is similar in the way different species age?
27:25 – Caenorhabditis elegans worm aging vs human aging
28:33 – Tortoises, shellfish vs warm blooded organisms
29:14 – Studying organisms closer to us in evolutionary terms: mammals
29:35 – The Pro aging argument: desirability vs viability
30:18 – The 50-50 chances of living indefinitely for those in middle age today
31:30 – The storytelling argument vs exploring novelty and diversity
33:20 – The pro-aging trance: a psychological coping mechanism
34:30 – The boredom argument: alzheimer at 80 vs bored at 150
34:59 – Overpopulation: technology increasing the carrying capacity of the planet – Renewable energy, artificial meat, desalination, bacteria that eat plastic, etc
37:14 – Perception of risk: self-driving cars and the lowering of risks brought by technology
39:45 – Today’s pensions vs economic benefits of improvements in longevity
40:57 – Work & automation: developing a new attitude in life
41:45 – Longevity: attitude and motivations
43:44 – AGI – artificial intelligence – the artificial researcher – machine learning and drug discovery, impact on aging research
45:17 – Fixing aging in the brain vs the rest of the body
46:44 – Regulation and politics: the quick switch, the urgent need to develop anti-aging policies
51:14 – Nanobots and Xenobots: the utility of non-biological solutions to medical problems
53:14 – SENS Foundation and how to go faster
55:50 – Challenges ahead
57:05 – Making a difference in the world
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